An innovative sampling interface for monitoring flowing pharmaceutical powder mixtures

A chute was designed following the principles of Theory Sampling to minimize variations in powder flow and provide all particles flowing blends with same opportunity being selected as a sample. The design also reduces thickness allow analysis higher portion by near infrared spectrometer. that flowed through had Carr’s index values fluctuated between 23 25 percent, indicating passable flowability. fowling evaluation demonstrated there no accumulation at inspection window chute. mass rate profiles indicated system achieves steady-state approximately 30 s throughput kg/h which makes it suitable for continuous manufacturing operations. An in-line NIR calibration model developed quantify caffeine concentrations 1.51 4.52 % w/w. spectra obtained from each experiment minimal baseline variation. method robust changes up ±7 %. test concentration range 2.02 w/w 4.02 met dose uniformity requirements Ph.Eur. 9.0, chapter 2.9.47. Variographic done estimate analytical sampling errors yielded below 0.01 (%w/w)2. results showed this could be used line or other applications powders.